The objective of this study was to develop an MR-based technique for quantifying the deformation of articular cartilage during mechanical loading in an intact cadaver joint at high spatial and temporal resolution. A nonmetallic pressure device was constructed for applying loads of >1000 N to a femoro-patellar articulation within an extremity coil of a clinical 1.5 T MRI scanner. Digital image processing methods were used to determine the location- and time-dependent cartilage deformation in consecutive 2D fat-suppressed FLASH images. Additionally, three-dimensional reconstruction of the cartilage was performed from 3D fat-suppressed FLASH image data. During the first 10 min of static compression, thickness changes between 10 and 30% were observed. Thickness changes greater than 50% and volume changes of 20% were recorded after 3 h. The technique permits analysis of the load and time-dependent mechanical behavior of articular cartilage in its natural environment.
The multimodal BTO with brain perfusion imaging (HMPAO-SPECT) and quantitative blood flow monitoring (TCD) allows a hemodynamic stroke risk assessment prior to permanent occlusion of the ICA. The procedure is important for planning of the therapeutic strategy and for the preoperative dialogue with the patient. Embolic ischemic complications can not be predicted.
Der Einsatz der Sonographie zur zweidimensionalen Schnitthilddarstel!ung ist in Innerer Medizin, Urologie und Gynkkologie seit langem gelaufig. In neuerer Zeit wurde die Darstellung zweidimensionaler Ultraschallschnittbilder mit hoher Detailauflosung auch zur Beurteilung extrakranieller Gefkl'stenosen des Halses sowie zur Schilddrüsen-und NebenschilddrUsendiagnostik eingesetzt (8). Die Abklarung unbekannter Haistumoren sowie die Suche nach regionalen Lymphknotenmetastasen bei bekannten Kopf-Ha!s-Tumoren stützen sich bislang naheu aussch!ie11ich auf die Computertomographie, während hochauflösende Ultraschallgerate hierbei bislang keine breite Verwendung finden (3, 5-7).
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