The investigation was carried out to determine the susceptibility of ABO blood groups to malaria parasiteamia among residents of Awka, Awka South L.G.A, Anambra State Nigeria. The research revealed that out of 309 samples analyzed for ABO blood groups susceptibility for malaria in various classes, 265 (85.8%) was observed to have patent parasiteamia with malaria. Among the sexes, males recorded higher susceptibility than females, with blood group B recording highest (94.5%) susceptibility of infection than other blood groups.The ABO and Rhesus blood group phenotype sample were determined by agglutination method using commercially provided antisera suitable for the detection of blood rhesus positivity and negativity.