-The reason science is taught in schools is not only to inspire students to choose careers in science and technology but also to equip them with practical knowledge of how things work, build their science literacy to enable informed participation in science-related debates and issues, and develop their skills in scientific thinking and their knowledge of science as part of their intellectual enculturation.This paper presents ScienceInvestigatory Project as a learning activity that is attuned with 21 st Century Education. Students were given opportunities to be engaged in exploring and solving socially relevant issues. They had hands-on experience on how scientific method works by designing their own fair tests, performing experiments showing cause-and-effect relationships, presenting and analyzing results through trends in graphs and communicate their results through a school-wide science fair. This learning activity engages students to be creative innovators by refining their method of investigating a problem; information literate by accessing reliable information through literature reviews; problem solvers by conducting experiments to verify their hypothesis; collaborators by working with partners and experts; communicators by writing a scientific paper, making display boards and orally present their findings; and, responsible citizens by coming up with a scientifically-verified solution to a problem. Index Terms -21st century learning, science investigatory project, learning by inquiry.