Edible: By grafting natural peptide antagonists onto the cyclotide kalata B1, orally active peptides were engineered, which are potentially useful therapeutics for the treatment of inflammatory pain. For example, the entire loop 6 of kalata B1 was replaced with the peptidic bradykinin B1 receptor antagonist DALK (red in scheme) to obtain the cyclic bradykinin antagonist ckb‐kal.

A finite element formulation for a digital image correlation method is presented that will determine directly the complete, two-dimensional displacement field during the image correlation process on digital images. The entire interested image area is discretized into finite elements that are involved in the common image correlation process by use of our algorithms. This image correlation method with finite element formulation has an advantage over subset-based image correlation methods because it satisfies the requirements of displacement continuity and derivative continuity among elements on images. Numerical studies and a real experiment are used to verify the proposed formulation. Results have shown that the image correlation with the finite element formulation is computationally efficient, accurate, and robust.

Essbar: Durch Aufpropfen von natürlichen Peptid‐Antagonisten auf das Cyclotid Kalata B1 wurden Peptide hergestellt, die nützliche oral verabreichbare Schmerzmittel sein könnten. Zum Beispiel wurde die gesamte Schleife 6 von Kalata B1 durch den peptidischen Bradykinin‐B1‐Rezeptor‐Antagonisten DALK (rot im Schema) ersetzt, um den cyclischen Bradykinin‐Antagonisten ckb‐kal zu erhalten.