Background-Octreotide treatment of acromegalic patients increases the 0/0 deoxycholic acid conjugates and the cholesterol saturation ofgall bladder bile, and induces gall stone formation. Aims-To study the roles of gall bladder emptying and intestinal transit in these phenomena. Methods and patients-Gall bladder emptying and mouth to caecum transit was measured in (a) control subjects and acromegalic patients given saline or 50 Kug ofoctreotide, and (b) acromegalic patients taking long term octreotide. In the second group, large bowel transit was also measured. Results-A single dose of octreotide inhibited meal stimulated gall bladder emptying, the ejection fraction falling from mean (SEM) 66-0 (2.3)% to 7.0 (5.3)0/o in controls (p<0'001); from 72-5

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