In an increasingly interconnected world, changes of uncertain nature and impact affect the functioning of human societies that depend on health, ecological, and economic systems. The proposed framework for systems-of-systems resilience explains ways of accommodating and responding to these challenges while encompassing the interfaces of the health, environment, and economy domains and their effect on communities. Resilience is defined as a continuous process and we distinguish between four system properties, five resilience capacities, and a variety of system activities.