Background: Menstrual cups have been available for decades, but their use is limited by bulky design and the need for multiple sizes. However, some benefits have been reported like improvement in managing health and hygiene during menstruation, better information on the average menstrual fluid discharged by women during menstruation and attainment of more knowledge bridging the lacuna in knowledge about the adaptability and efficacy of menstrual cup as a better alternative to conventional options. The study is aimed towards assessing the adaptability and the effectiveness of menstrual cup by naïve users who have been using sanitary pads/tampons/cloth as conventional menstrual sanitary protection.Methods: The study was conducted at conducted Gujarat Medical Education and Research Society, Medical College and Hospital, Dharpur, Patan, Gujarat, India. Total 158 participants aged between ages of 20 to 50 years with regular menstrual cycle were enrolled in the study. Participants were provided menstrual cups to be used for three consecutive menstrual cycles. They were given detailed explanation/information about its usage. Feedback was obtained after every cycle for three cycles using a structured questionnaire.Results: The cup was preferred for comfort, dryness, and less odor. Insertion was easy for 80% participants and 90% participants found removal easy. Problem of leakage was encountered in 3-6%. There were few side effects like rashes, dryness or infection.Conclusions: These results demonstrate that this reusable vaginal device has no significant health risks and is acceptable to many women without the need for fitting or other medical services.