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Objectives:To evaluate the neuroprotective effect of Stereospermum suaveolens DC on 6-hydroxy dopamine induced Parkinson's disease model.Materials and Methods:The study was conducted on Sprague-Dawley rats where parkinson's disease was induced by producing the striatal 6-hydroxy dopamine lesions. The test animals received methanolic extract of Stereospermum suaveolens at dose of 125, 250 and 500 mg/kg for 42 days. Behavioral assessment, spontaneous locomotor activity and muscular coordination were studied. Antioxidant levels, striatal infraction area were assessed and histopathological studies were carried out.Results:The Stereospermum suaveolens DC methanolic extract showed significant dose dependent increase in behavioral activity, improved muscular coordination. Significant reduction of lipid peroxidation (LPO), increased antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT) and non-enzymatic activity of glutathione (GSH) and total thiol levels in extract treated groups was observed in test groups as compared to control group. Striatal infarction area was significantly reduced in extract treated groups as compared to control group.Conclusion:The methanolic extract of Stereospermum suaveolens DC showed neuroprotective activity against 6-hydroxy dopamine induced Parkinson's disease in rats.

Objective: The present work was designed to formulate and optimize Orodispersible tablets of Piroxicam using QbD approach. The central composite design tool was used to evaluate the scientific understanding of input and output variables to construct design space for regulatory flexibility. Methodology: The concentrations of super disintegrants were selected as independent variables. The dependent variables selected were in vitro dispersion time and percentage drug release. The quantitative effect of independent variables at different levels on response variables was predicted using polynomial equations. The model was found to be nonlinear and the curvature effect was significant. Therefore study resorted to composite design for optimization. Results and Discussion: DSC studies indicated drug and excipients were compatible. Precompression para meters indicated fairly good flow properties. Tablets were prepared by direct compression method and all the tablets prepared in the above studies were evaluated for pharmacotechnical properties and were found to be within specified limits. Increase in the concentration of Sodium starch glycolate (SSG), Crospovidone (CP) decreased the in vitro dispersion time and increased percentage drug release. Kinetic studies revealed that drug release from all formulations followed first order release. The relationship between independent variables and dependent variables was further elucidated using contour plots. Based on these plots most economical batch was decided which were in desired range. This is an open access article distributed under the terms of the Creative Commons AttributionNonCommercialShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work noncommercially, as long as the author is credited and the new creations are licensed under the identical terms.

Granulation is an important unit process in the production of pharmaceutical dosage forms like tablets, capsules and other dosage forms. Granulation process increases flow, compressibility and content uniformity of the powders. It inhibits the separation of blend components and reduces excessive amount of fine particles. This process helps to achieve improved yields with less tablet manufacturing defects. Particle size of granules depends on the quantity and feeding rate of the granulating liquid. Selecting a method of granulation requires comprehensive study of each ingredient in the formula, the combination of ingredients and their compatibility with each other is checked after, which appropriate granulation process can be applied. The recent technologies used for granulation include steam granulation, moisture activated dry granulation (MADG), moist granulation technique (MGT), extrusion-spheronization granulation, fluidized bed granulation, thermal adhesion granulation process (TAGP) and foam granulation etc. have their own advantages and overcome the disadvantages of conventional granulation process such as dust generation or deteriorating effect of heat as drying step. The objective of present work is to focus on the novel granulation technologies.