SummaryA convenient synthesis of chloramphenicol labelled with carbon-14 in the dichloroacetyl group at the 1 position is described. It was prepared as part of a 4-step sequence from [1-14 C] glycine and the product was purified by preparative HPLC.A radiochemical yield of 47% was obtained based on [1-14 C] glycine and the product had a specific activity of 0.47 mCi/mmol. The procedure can be employed for the synthesis of high specific activity [ 14 C] chloramphenicol, labelled at 1, 2 or both the positions of dichloroacetyl group.

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