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NOTES tion; heat resistance, stainability, and optical density were unchanged. On the other hand, at 75 C in caramelized glucose, spores of this organism and several other Clostridium strains have shown progressive loss of heat resistance. Since DPA release at 75 C from spores in water and in caramelized glucose was entirely comparable, the results do not elucidate the question of possible germination in carmelized glucose at 75 C.

Induction by antibiotics and comparative sensitivity of L-phase variants of Staphylococcus aureus. J. Bacteriol. 88:591-594. 1964.-The penicillins, cephalothin, vancomycin, and bacitracin were found to be less inhibitory to the L-phase variants than to their respective parent bacteria. Those antibiotics not considered to be primarily inhibitors of cell-wall synthesis were, in general, somewhat more inhibitory to the L form than to their parent bacteria. Only the penicillins and cephalothin readily induced L-phase variation. Novobiocin induced pleomorphic growth resembling the earliest stages of L-phase transformation. Failure of observable induction by bacitracin and vancomycin suggests that these two antibiotics affect cell-wall synthesis in a manner different from the penicillins, or that L-phase transformation may require more than "penicillin-like" interference with cell-wall synthesis.