High intensity exercise and sports activities are closely related to a general state of inflammation that can lead to immunosuppression. This physiological response could decrease sports performance and even compromise the athlete's health. The objective of this study was to investigate the acute inflammatory response of a padel match. 15 elite players (28.2±7.9 years) participated voluntarily in the study. Different pro-inflammatory (IL-1ß, IL-2, IL-6, IL-7, IL-8, IL-12 and TNFa) and anti-inflammatory cytokines (IL-5, IL-10 and IL-13) were analyzed before and after a match. The results showed a decrease in IL-7 (p=0.007) and IL-8 (p<0.03) and increases in IL-10 (p<0.04). The results obtained suggest that the practice of high-level padel induces an anti-inflammatory response.