In the process of coupling disaster prevention and control of gas and coal spontaneous combustion in goaf, there is a great contradiction between the gas drainage and carbon dioxide inerting technology. The key performance indexes are put forward to solve the coupling disaster, such as the air quantity of the intake airway (A), the gas drainage rate (B), the carbon dioxide injection rate (C), and the injection depth (D). Using the numerical simulation method and the orthogonal test of four factors and three levels, we establish the coupling disaster model of the no. 7436 working face in the Kongzhuang coal mine. Using a combination of the relative membership degree method and range analysis, the optimal level of each factor is determined, which is A II B III C II D II . Furthermore, the distribution law of the airflow field is obtained under the conditions of different gas drainage rates and carbon dioxide injection rates. The results show that the gas concentration decreases with an increase in gas drainage in the upper corner, but it has little impact on the width of the oxidation zone. The gas concentration can be reduced to 1%, while the gas drainage rate is higher than 35 m 3 /min. With an increase in gas injection rate, the carbon dioxide emission rate increases in the upper corner, but the width of the oxidation zone decreases. Also, the gas injection rate should be less than 800 m 3 /h. Moreover, with an increase in injection time in the upper corner during the injection process, the carbon dioxide and gas concentrations increase, and the maximum carbon dioxide concentration is 1.3%, and the maximum gas concentration is 0.42%, which is consistent with the results of numerical simulations.