A systematic review of research published in English was conducted across seven electronic databases in public health, social and psychological sciences. The aim was to ascertain the factors that influence condom use among female sex workers in the commercial sex industry globally. The perspectives and experiences of 29,112 female sex workers (FSWs) and 1,792 male clients of FSWs with regards to condom use are represented across the 47 studies included in this review. Key themes comprised of Perceived self-efficacy, Relationship Types, Condom use and Attitudes, Violence and Abuse, Location and Support, Knowledge and Perceived Risk, Perception and Perspectives of Male Clients, Drug and Alcohol use, Criminalisation and Price and Payment. Female sex workers are defined as a high-risk population for HIV/AIDS. Condoms were used less frequently in situations where structural and cultural determinants heavily impacted the experiences and decisions of FSWs. Cultural contextual factors also heavily impacted on the perspectives and perceptions of male clients and their attitudes towards condom use. Criminalization and anti-sex work legislation in many of the countries where these studies were conducted meant that FSWs were a socially marginalised and ostracized population. Recommendations are explored for theory, practice and education and future research.