Introduction: Down syndrome individuals have different gait patterns, which include specific characteristics such as foot rotation asymmetry. Objective: The aim of this study was to analyze the relationship between this asymmetry and the previous acquisition of hands-and-knees crawling in Down syndrome children, as well as the probable association of this gait to gender, ethnicity, comorbidities, physiotherapy, and occupational therapy interventions. Methods: In this cross-sectional study, 361 children with or without foot rotation asymmetry were selected. An online questionnaire was administered to the parents or guardians of those children. Results: Hands-and-knees crawling decreased the prevalence of foot rotation asymmetry in Down syndrome children. The longer it took for walking onset, the higher the prevalence of this asymmetry. Indeed, for each month of delay there was a 7% increase in prevalence. There was a significant relationship between orthopedic alterations in knees or flat feet and foot rotation asymmetry. There was no significance related to gender, ethnicity, other comorbidities, physiotherapy or occupational therapy interventions. Conclusion: The findings in this study revealed that foot rotation asymmetry may be related to the acquisition of the motor skills described above, especially with regards to hands-and-knees crawling and walking onset.

O riluzole tem sido usado para o tratamento da Esclerose Lateral Amiotrófica (ELA). Estudos experimentais têm mostrado inibição do crescimento tumoral com riluzole. O objetivo desta revisão sistemática foi analisar as potencialidades do tratamento de cânceres com uso de riluzole. Foram investigadas publicações científicas nas bases Web of Science, Scopus e Pubmed de 2007 a 2021 com os termos câncer e riluzole. A discussão mostra a relação do glutamato com o câncer e como o riluzole atua como um importante inibidor da sinalização deste componente relacionado com a taxa de crescimento e invasibilidade de tipos específicos de câncer. A maioria dos diferentes estudos in vitro, in vivo ou em humanos relata que o riluzole tem se apresentado como uma droga promissora no tratamento de tipos específicos de câncer. No entanto, mais pesquisas tornam-se necessárias antes de conclusões definitivas sobre o uso de riluzole para diversos tipos de câncer. Palavras-chave: Neoplasias; Riluzole.