In this era of machine learning being applied to various fields, its use in college Two courses education has gradually become the next outlet. The reform and innovation based on machine learning is an upgrade that must be carried out in Two courses education. In this experiment, the purpose of predicting the effect of Two courses classroom teaching is achieved by rationally using the Apriori algorithm in the machine learning algorithm to construct a prediction model. After modeling and verification, it has been shown the prediction model of Two courses classroom and extracurricular teaching effect using the machine. Apriori algorithm technology can enhance the participation and interaction of Two courses education, stimulate the interest of college students in Two courses education, and improve their enthusiasm. The selection and basic information of Apriori algorithm and the prediction for practical application have been studied. The accuracy of the prediction model is investigated. Compared with the logistic regression algorithm, it is concluded that the model established by the Apriori algorithm selected in this experiment has higher accuracy. Finally, the prediction model is organically integrated into the Two courses of a university carefully selected by the experiment. After a semester of intensive use, and then algorithm effects, the difference in accuracy is no more than 2%, far better than the expected 6%.