The design and synthesis of new Nanomaterials applied for Bio-applications as Nanosensors of single molecule detection, Biosensors of biological events and controlled drug delivery nanoparticles are of high interest and impact in bioanalytical methodologies, clinical research and as well as from new areas of research as Nanophotonics, Biophotonics, and Nanomedicine. First, one of the higher challenges within all these research fields is how to transduce an analytical signal and transduce it from individual biological events or biomolecules. And at the same time secondly, it should be tracked biological event during the time by a selective response followed by a given therapy action depending of needs. In order to afford these challenges the control at the nanoscale incorporating different types of materials from hybrids Nanomaterials to Metamaterials for variable and biocompatible properties for targeted applications. Due to the high impact, if it is tuned these properties based on specific requirements new therapies within Precision medicine are open. For these reasons, in this short Review was exposed different strategies for Smart tunable Nanoarchitectures as Nanoplatforms for Bioconjugation to design Lab. On-particle and Drug delivery Nano-systems accompanied with Luminescent and Ultraluminescent properties based on Fluorescence Resonance Energy Transfer (FRET), Metal Enhanced Fluorescence (MEF), Enhanced Plasmonics (EP) coupled to MEF as well as FRET coupled to MEF applied for early diagnosis, biomolecular and DNA detection, Genomics, Gene therapies and Drug Delivery Systems by the application of synthetic and Bio-inspired Nanoarchitectures based on Hybrids Nanomaterials. By this manner advanced treatments in-situ or in vivo after stimulation by a smart bio-response were discussed.

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Fluorescent silica nanophotonics for cyanobacteria labelling.

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