A study has been made of the colloidal osmotic pressure of human sera and pathological accumulation of fluids in an effort to gain information concerning the relations of semipermeable membranes and biological colloids and particularly to determine in serum the osmotic effects of the important colloids, albumin and globulin.

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A sharp contrast has been demonstrated in regard to the post-operative amylase concentration of the sera of dogs, depending upon whether ligation of the pancreatic ducts was or was not a part of an otherwise prescribed operation. The characteristic feature is a marked rise of several hundred per cent in serum amylase concentration, sustained for several days, which is observed when the pancreatic ducts have been ligated.

FIG. 1.Conclusiom: 1. The subcutaneous administration o f tyramine hydrochloride to rabbits in amounts from 0.1 mgm. to 20.0 mgm. per kilo of body weight was followed by an increase in the number of red corpuscles per cubic millimeter in the circulating blood. 2.The repeated subcutaneous administratioil of a fixed amount of tyramine hydrochloride to rabbits was accompanied by a progressive increase in the number of red corpuscles per cubic millimeter in the circulating blood. The results in these experiments resemble those obtained when a secretin preparation was administered to rabbits (Downs and Eddy'. '). 786Amylase Studies in Dogs Sera Following Ligation of the Pancreatic Ducts.

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