Psychotropics medications act on the central nervous system and are used in the treatment of mental disorders or psychiatric disorders. Since they cause tolerance and dependence, they must have controlled and exclusive dispensation of pharmacists complying into Ordinance No. 344/98 of the Brazilian Ministry of Health. However, it's use in an abusive manner is increasingly common, which can lead to exogenous intoxications and deaths. The main objective of this monograph was to emphasize the importance of the pharmacist in guiding the prevention the recurrence of intoxications by these types of medications. The method used in the research included a literature review carried out by gathering information on the main publications collected in the virtual databases from 2013 to 2020, in addiction to epidemiological data available at the National Poisoning Information System (SINITOX) from 2015 to 2017 and several books, laws, resolutions and ordinances on the subject. This analysis brought important final considerations about the key role of the pharmacist as an interceptor in these situations, since it's the last health professional to intervene before the user takes his medication. In the act of dispensing medications, after a careful evaluation of the medical prescription, the pharmacist should guide the patient emphasizing the fulfilment of the dosage, the harm of interaction with other drugs and alcohol, the recognition of potential adverse reactions and the problems that overdose may cause. In this way, it will seek to provide the rational and safe use of medicines, and will ensure effectiveness and therapeutic safety.