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one SNP at a time with the new software (PSQHS 96A) from Pyrosequencing AB is likely to speed up haplotype analysis. When pyrosequencing data for DPYD*5, DPYD*2A, DPYD*9A, and DPYD*6 were analyzed using the Polymorphism Haplotype Analysis Suite (PHASE), Ver. 0.9 (21 ), almost 90% of all Caucasian samples had one of the following three haplotypes (in the order DPYD*5, DPYD*2A, DPYD*9A, and DPYD*6): AGTG (63%), GGTG (16.5%), and AGCG (14.6%). However, the second most common Caucasian haplotype was seen in Ͻ5% of the African samples. This highlights the importance of comparing haplotype composition among different world populations before applying haplotype structure to clinical studies.In conclusion, the technology from Pyrosequencing AB is a faster and more efficient SNP evaluation method than is RFLP analysis. With the reduction in the amount of reagents used and the available software, cost is less of an obstacle for high-throughput SNP analysis in large population studies. This could aid in the rapid and efficient analysis of SNPs in many genes that encode drug-metabolizing enzymes in several patient and population sets in an effort to tailor drug therapy based on the genetic make up of an individual.

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This is one of the first report on adiponectin in benign and malignant gynecological diseases. Future studies are needed to address the clinical potential role of adiponectin in cancer.