Title: Spinal cord injury induced hyperalgesia is associated with increased levels of Let-7 family of MicroRNAs.Background: Spinal cord injury (SCI) results in chronic pain syndromes that are often refractory to treatment with opioids, and may represent mu opioid receptor (MOR) dysfunction. MicroRNAs play a role in gene regulation by binding to target mRNA, causing translational repression or mRNA degradation. Let-7 family microRNAs have been shown to target MOR suggesting they may influence the development of pain states and opioid responsiveness. This study sought to determine temporal changes in Let-7 family miRNA and correlate them to the onset of pain behaviors in a rodent model of post-SCI pain.
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