A obra que ten nas mans ofrece unha escolma da produción como articulista, ensaísta, narrador, dramaturgo e poeta de Ramón Otero Pedrayo, autor dunha vastísima obra, a máis voluminosa que ningún outro escritor galego teña feito ata agora, que non se pode desligar do compromiso que adquirira en 1918, cando empezara a participar activamente no movemento político e cultural iniciado polas Irmandades da Fala. Con moi raras excepcións, toda ela versa sobre Galicia. Como narrador é un dos fundadores da moderna prosa galega, podéndose dicir que o papel que respecto da lírica desempeñaron os poetas no século XIX, dun xeito especial Rosalía, Pondal e Curros, é o que a el lle corresponde no século XX no campo da épica.

Loss of HLA class I expression on tumor cells is a frequent event as an immune escape mechanism. Seven different altered HLA phenotypes have been defined in tumors. Various molecular mechanisms have been described as responsible for HLA class I loss. HLA class I expression alterations occur successively and unpredictably during tumor progression in vivo and immunoselection has been implicated in this process. We present an experimental xenograft model in which melanoma cell line Ando-2 injected into athymic nude mice lost total surface HLA class I expression and exhibited HLA class II cell surface expression. A strong down-regulation of HLA class I expression and de novo HLA class II expression were also found when Ando-2 melanoma cells were injected into SCID-Beige mice. These phenomena were reproducible and were only observed in local growth in nude or SCID-Beige mice and not in vitro after multiple passages. HLA class I surface expression was recovered after IFN-c treatment, indicating regulatory defects. The mechanism implicated in loss of HLA class I molecule expression were a down-regulation of different components of antigen processing machinery and HLA class I heavy chains. These data suggest that HLA class I alterations can also occur in absence of autologous adaptive immune response. This is a good experimental in vivo model to study the relationship between tumor progression and HLA class I alterations. ' 2007 Wiley-Liss, Inc.

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Desde que se publicaron os seus primeiros libros na década dos anos cincuenta, Ánxel Fole pasou a ser un dos narradores galegos máis apreciados polos lectores. Os seus relatos, que el quixo que tiveran as maneiras e o estilo dos contos populares, situaron o seu autor nun lugar preeminente na literatura do século XX. Escolma de textos e introdución biográfica de Ánxel Fole realizadas por Carlos Casares co gallo do Día das Letras Galegas de 1997.