Evaluation of liver regeneration diet supplemented with omega-3 fatty acids: experimental study in rats 393Rev. Col. Bras. Cir. 2015; 42(6): [393][394][395][396][397] Original Article Original Article Original Article Original Article Original Article DOI: 10.1590/0100-69912015006008 Evaluation of liver regeneration diet supplemented with omega-3 Evaluation of liver regeneration diet supplemented with omega-3 Evaluation of liver regeneration diet supplemented with omega-3 Evaluation of liver regeneration diet supplemented with omega-3 Evaluation of liver regeneration diet supplemented with omega-3 fatty acids: experimental study in rats fatty acids: experimental study in rats fatty acids: experimental study in rats fatty acids: experimental study in rats fatty acids: experimental study in rats Avaliação da regeneração hepática com dieta suplementada com ácidos graxos Avaliação da regeneração hepática com dieta suplementada com ácidos graxos Avaliação da regeneração hepática com dieta suplementada com ácidos graxos Avaliação da regeneração hepática com dieta suplementada com ácidos graxos Avaliação da regeneração hepática com dieta suplementada com ácidos graxos ômega-3: estudo experimental em ratos ômega-3: estudo experimental em ratos ômega-3: estudo experimental em ratos ômega-3: estudo experimental em ratos ômega-3: estudo experimental em ratos Objective Objective: to evaluate liver regeneration in rats after partial hepatectomy of 60% with and without action diet supplemented with fatty acids through the study of the regenerated liver weight, laboratory parameters of liver function and histological study. Methods Methods Methods Methods Methods: thirty-six Wistar rats, males, adults were used, weighing between 195 and 330 g assigned to control and groups. The supplementation group received the diet by gavage and were killed after 24h, 72h and seven days. Evaluation of regeneration occurred through analysis of weight gain liver, serum aspartate aminotransferase, alanine aminotransferase, gammaglutamyltranspeptidase, and mitosis of the liver stained with H&E. Results Results ResultsResults Results: the diet supplemented group showed no statistical difference (p>0.05) on the evolution of weights. Administration of fatty acids post-hepatectomy had significant reduction in gamma glutamyltransferase levels and may reflect liver regeneration. Referring to mitotic index, it did not differ between period of times among the groups. Conclusion Conclusion Conclusion Conclusion Conclusion: supplementation with fatty acids in rats undergoing 60% hepatic resection showed no significant interference related to liver regeneration.

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PURPOSE: To study the macro and microscopic evaluation of the damage caused by clamping or section of cervical sympathetic nerve in rabbits, quantifying the collagen in the lesions. METHODS: Twenty rabbits were divided into two groups of ten, doing in group 1 (section) section of the right cervical sympathetic nerve, while in group 2 (clipping) clipping of the nerve. All rabbits were induced to death on the seventh day after surgery. The macroscopic variables were: consequences of nerve lesion, clip appearance, presence of infection and adhesions around the nerve. Microscopy used hematoxylin-eosin staining to evaluate the stages and the degree of inflammation and necrosis, and F3BA Picrosirius red staining to quantify collagen. Mann-Whitney test was used for comparisons of collagen types I and III between groups. Fisher exact test analyzed the macroscopic variables, the degree of inflammation and necrosis. RESULTS: There was no discontinuity of nerve injury in the clipping group, as well as the clip was closed in all animals. The presence of severe adhesions was significantly higher in the clipping group (p<0.05). There was no significant difference on other variables macroscopically analyzed. There was no significant difference between groups regarding the type of inflammatory process and its intensity, as well as the presence of necrosis and collagen deposition in the nerves. CONCLUSIONS: In the macroscopic evaluation, the section caused discontinuity, which did not occur in the clamping group; there was no development of local infection; the clipping of the cervical sympathetic nerve was linked to the presence of a greater number of adhesions in comparison to the section group. Microscopically, no difference existed in relation to the type and intensity of inflammation reaction between the groups; occurred predominance of chronic and severe inflammation on the specimens; the necrosis was noticed equally in both groups; there was predominance of type I collagen deposition in relation to type III in both groups.

RESUMO –A tetralogia de Fallot é a cardiopatia congênita cianótica mais comum. Caracteriza-se por tétrade de malformações anatômicas que incluem estenose pulmonar, defeito do septo ventricular, hipertrofia do ventrículo direito e dextroposição da aorta (cavalgamento da aorta). O objetivo deste estudo foi analisar e descrever as alterações anatômicas cardíacas, tratamento e prognóstico de pacientes com a doença. É revisão narrativa de artigos indexados na base de dados PubMed, Google Acadêmico e LILACS utilizando os descritores “tetralogy of Fallot”, “congenital heart disease”, “cyanotic disease”. Em conclusão, a tetralogia de Fallot é cardiopatia congênita comum e com prognóstico ruim caso não seja realizado diagnóstico e tratamento precoces. O seguimento médico contínuo e próximo ao paciente é importante para acompanhar a evolução e programar novas intervenções caso necessárias.

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