To study the effect of meals on PRL secretion, serum PRL was measured after the ingestion of mixed meals and specific single macronutrients by normal men and women. In men, only protein feeding significantly stimulated PRL secretion. In women, protein meals as well as a standard mixed meal and a liquid mixed meal resulted in PRL release. Fat, glucose, and a nonnutrient meal had no consistent effect on serum PRL. Serum TSH was not altered by any of the meals, and serum GH and cortisol showed few changes. We conclude that PRL stimulation by meals may be of occasional clinical significance, principally in confusing the diagnosis of hyperprolactinemic states, especially in women. Dietary protein is probably the agent responsible for PRL secretion induced by meals.
Demam merupakan sebuah proses alamiah yang timbul sebagai mekanisme pertahanan tubuh terhadap patogen, namun terkadang suhu yang terlalu tinggi seringkali menjadi suatu dilema sendiri yang menimbulkan kekhawatiran pada orangtua. Demam terjadi karena peningkatan pusat pengatur suhu di hipotalamus yang dipengaruhi oleh Interleukin-1 (IL-1). Terdapat berbagai variasi kisaran suhu normal pada anak menurut tempat pengukurannya. Tatalaksana demam yang terutama yaitu pemberian antipiretik seperti parasetamol atau ibuprofen. Beberapa studi menemukan bahwa penggunaan metode kombinasi antipiretik memberikan efek antipiretik yang lebih tinggi, namun hal ini belum dapat direkomendasikan karena belum ada studi mengenai keamanannya. Metode kompres hangat juga dapat diberikan sebagai terapi tambahan untuk membantu menurunkan demam pada anak. Penggunaan antipiretik sesuai dosis yang direkomendasikan ditambah dengan kompres hangat sudah terbukti lebih efektif untuk menurunkan demam pada anak terutama di 30 menit pertama. Kata Kunci : Demam, Interleukin-1, Kompres, Tepid Sponging
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