The most relevant aspects of the relationship between stroke and hematological disorders are reported. A high index of suspicion is needed in young stroke patients, patients with recurrent stroke of undetermined cause, and in patients with prior history of venous thrombosis to identify a potential hematological disorder as the definitive etiology of stroke Expert commentary: Stroke can be the presenting manifestation of a specific hematological disease or may appear as a complication in the course of hematological disorders. It is important to make a correct diagnosis of the underlying hematological disorder in order to treat stroke patients promptly and appropriately as well as to establish the optimal secondary prevention strategy for recurrent vascular cerebral disease.

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Highly Stereoselective Titanium-Mediated Aldol Reactions from Chiral α-Silyloxy Ketones. A Reliable Tool for the Synthesis of Natural Products. -The influence of substitution pattern of α-siloxy ketones on the reactivity in Ti-mediated aldol reactions is studied. The reaction affords syn,syn-products with excellent diastereoselectivity, irrespective of the substituents applied. Further manipulation of the initial aldol adducts is studied, including removal of the original stereocenter [cf. (V)] and stereoselective reduction of the carbonyl group [cf. (XI)]. A variety of polyol derivatives can be achieved, which represent key subunits of natural or bioactive products [cf. NFX-2 (IX), antimycinone or salinomycin]. -(ESTEVE, J.; JIMENEZ, C.; NEBOT, J.; VELASCO, J.; ROMEA*, P.; URPI, F.; Tetrahedron 67 (2011) 33, 6045-6056, http://dx.