Xanthogranulomatous pyelonephritis (XGP) is a rare and severe manifestation of chronic kidney inflammation that can be critical if not recognized and treated appropriately, often requires surgical intervention along with antibiotics. Most commonly presented in the fifth or sixth decade of life with a prior history of nephrolithiasis, obstructive uropathy, or recurrent urinary tract infections. Here, we discuss a 45-year-old male and a 73-year-old female who came with abdominal pain and weight loss for two months. An enlarged and distorted renal outline, with altered echotexture and calculus in renal pelvis was revealed on ultrasound examination. Abdominal computed tomography revealed staghorn renal calculi and thinning of renal cortex with involvement of adjacent structures.