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Background/aim Prevention of hypoglycemia remains a major challenge in diabetic management, despite the introduction of modern insulin pumps in daily clinical practice. The Low Glucose Suspend (LGS) and the newer Predictive Low Glucose Management (PLGM) systems incorporated in the Medtronic insulin pumps have shown promising results in prevention of hypoglycemia. Our aim was to evaluate the effect of the 2 systems relative to the frequency of clinically significant hypoglycemia in Type 1 diabetes (T1DM). In addition, we investigated the events preceding clinically significant hypoglycemia episodes. Methods A cross-sectional study was conducted in 30 T1DM patients using the MiniMed 640G vs. 30 using the MiniMed Veo sensor-augmented insulin pump. All data was recorded during patients’ normal daily activity and living conditions. The patients were matched for age and duration of diabetes. Results PLGM use was associated with lower incidence of clinically significant hypoglycemia (1.9±1.4 vs. 3.6±1.9 episodes per week), along with reduced exposure to hypoglycemia. The data indicated that both pump systems are effective in preventing severe hypoglycemic episodes. In both groups the most common events preceding hypoglycemic episodes included adjustment of hyperglycemia, basal rate increase and miscalculation of carbohydrates. Conclusions The results indicated that the use of the Minimed 640G pump system can help reduce the frequency of clinically significant hypoglycemia. Management of hyperglycemia must be addressed in diabetes education programs in order to encourage proper adjustment of high blood glucose levels. Future studies would be useful in exploring the details of the events preceding hypoglycemia episodes in insulin pump users.

The prevalence of adverse outcomes in GDM pregnancies compared to the general population are still high in studies, which used ADA treatment criteria. Our goal was to compare outcomes of tight controlled GDM pregnancies achieving optimal glycemic patterns with normal pregnancies. A cross-sectional study of 280 singleton pregnancies: 140 GDM with a mean FBG ≤90 and 1h PP ≤ 120mg/dL vs. 140 normal pregnancies, age and BMI matched. FBG and 1h PP BG for each participant was determined by the average of their SMBG readings. Clinical characteristics - age: 35.7±5 vs. 35.4±5 years; BMI: 23.1±5 vs. 23.7±4 kg/m2; OGTT 0’: 94.1±14.4, 60’: 186.1±27.7, 120’: 161,2±20.4 mg/dL; HbA1c: 5.2±0.6 vs. 4.8±0.3 %, p<0.001; FBG: 83.7±8 mg/dl; 1h PP BG: 106.5±11 mg/dl; GDM diagnosis week: 25.8±4; starting insulin week: 26.8±5; insulin dose: 46.3±13 iu/day. Obstetric and neonatal history between groups: Weight gain: 11.8±4 vs. 10.4±2 kg, p=0.03; delivery week: 37.7±2 vs. 38.1±1, p=0.01; neonatal birth weight: 3050±327 vs. 3200±355 g, p<0.001; SGA: 5.7 vs. 4.3%; LGA: 5.7 vs. 3.6 %; women hypoglycemia episodes: 21.4 %; pre-eclampsia rate: 4.2 vs. 2.8 %; RDS: 10 vs. 7.1 %; Neonatal hypoglycemia: 6.4 vs. 5.7%, NICU admittance: 17.8 vs. 6.4%, p=0.02, Caesarean section: 60 vs. 23.6 %, p<0.001. No cases of severe maternal hypoglycemia and perinatal mortality. An association between: maternal-fetal complications and increased 1h PP BG (r=303), 1h (r=348), 2h (r=228) OGTT values. No association between adverse fetal outcome and maternal hypoglycemia. Tight metabolic control with early insulin therapy minimizes adverse pregnancy outcomes. Performing GDM screenings before 24-28 weeks in women >35 years of age is recommended. Outcome of the pregnancies was not adversely affected by maternal hypoglycemia. 1h PP BG and 1h and 2h OGTT values predicts outcome in GDM pregnancies. More research is needed to understand the optimal BG targets in GDM management. Disclosure P. Thomakos: None. O. Kepaptsoglou: None. C. Barreto: None. A. Trouva: None. D. Trouvas: None. C.S.P. Zoupas: None.

Este artigo visa elaborar uma análise introdutória dos discursos expressos por meio da aparência e da moda, considerando a sua presença como um suplemento ao corpo, e à materialidade do gênero em suas várias posicionalidades, através dos marcadores sociais das diferenças — raça/etnia, gênero, sexualidade, orientação afetivo-sexual, geração, classe social dentre outras categorias — com as quais moda, aparência e corporalidade se articulam. Propõe-se que se pense moda a partir dos seus processos criativos, com ênfase no estudo da diferença, a fim de promover uma abrangência maior de sua atuação, a despeito dos estudos gêneros tradicionais que encaram o assunto sob a perspectiva feminina e hegemônica.

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