Nurses working in the outpatient ambulatory setting treat patients with multiple infusion drug regimens. Patients can have allergic reactions to infusions ranging from very mild to life-threatening. The reaction and the subsequent treatment measures can be very disconcerting to the patients and to the visitors in the infusion area. The nursing team described in this article took a proactive approach to minimize infusion reactions in the authors' facility, thereby ensuring the safety of other patients. Staff members examined the performance improvement data, conducted a retrospective study, and collaborated with the primary physician providers to develop rechallenge protocols for patients receiving paclitaxel and carboplatin regimens.