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Polycitone B (2) was obtained in four steps from pyrrole dicarboxylic acid 3, including Friedel-Crafts reaction of the corresponding acid chloride with anisole. The conversion of 2 into polycitone A (1) was achieved in two steps via Mitsunobu alkylation of the pyrrolic NH group. The synthesis of polycitone A proceeds in 18% overall yield and offers the possibility of varying the substituents on the pyrrole ring.

DNA synthesis after treatment with cortisol is not the result of a direct interference with a biosynthetic pathway, but is simply a res1<1lt of the reduction in the number of cells able to incorporate thymidine. Other effects of cortisol on lymphatic tissue, such as decreased glucose utilization and decreased protein synthesis, als@ may be U10 result of this phenomenon.

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