As an illustration of women's representation in clinical research, a comprehensive literature review of HIV/AIDS-related neuropsychological research was conducted. The goals of this study were to document whether women have been included in (a) HIV-related neurological and neuropsychological research studies; (b) percentages comparable to their representation in the population of persons with HIV/AIDS; (c) studies using numbers sufficient to allow data analyses by sex (N ≥ 30); and (d) data analyses conducted to examine sex differences. Women were included in half of the studies investigating neurological and neuropsychological manifestations of HIV between 1988 and 1997 (236 studies). However, their representation was inadequate to determine whether there were reliable sex differences in these complications. It is not simply enough to include more women; researchers must also strive to increase the quality of studies to ensure that women's contribution is clinically and empirically relevant.

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