Background. Cutaneous leishmaniasis (CL) caused by Leishmania braziliensis remains animportant public health problem in Brazil. The goal of this study was to identify genetic risk factors for CL.Methods. Genome-wide analysis was undertaken using DNAs from 956 CL cases and 868 controls (phase 1) and 1110 CL cases and 1178 controls (phase 2) genotyped using Illumina HumanCoreExome BeadChips. Imputation against 1000G data provided 4,498,586 qualitycontrolled single nucleotide variants (SNVs) common across phase 1 and phase 2 samples.Linear mixed models in FastLMM were used to take account of genetic diversity/ethnicity/admixture. Cellular cytokines were measured using flow cytometry.