Football (soccer) is a high-intensity intermittent sport with large energy demands. In a repeated-measures design, we analysed the nutritional intake and training load of fourteen female football players (22.50 ± 4.38 y; 57.23 ± 8.61 kg; 164 ± 6.00 cm; 18.33 ± 2.48% of fat mass and 23.71 ± 2.51 kg of muscle mass) competing in the highest female Football Portuguese League across a typical mid-season microcycle. The microcycle had one match day (MD), one recovery session (two days after the MD, MD+2), three training sessions (MD-3, MD-2, MD-1) and two rest days (MD+1). Energy intake and CHO (g.kg.BW−1) intake were lower on the days before the competition (MD+2, MD-3, MD-2 and MD-1 vs. MD; p < 0.05; ES: 0.60–1.30). Total distance, distance covered at high-speed running (HSRD) and the high metabolic distance load (HMLD) were lower on MD+2, MD-3 and MD-1 compared with MD (p < 0.05; ES: <0.2–5.70). The internal training load was lower in all training sessions before the competition (MD+2, MD-3, MD-2 and MD-1 vs. MD; p ≤ 0.01; ES: 1.28–5.47). Despite the small sample size and a single assessment in time, the results suggest that caloric and CHO intake were below the recommendations and were not structured based on the physical requirements for training sessions or match days.

To the Editor, Interstitial lung abnormalities (ILAs) are a radiological entity characterized by incidental findings in chest computed tomography (CT) scans, with specific patterns of modifications in lung density in patients with no prior history of interstitial lung disease. These radiologic changes are present in more than 5% of nondependent lung parenchyma areas. And they include reticular abnormalities or groundglass attenuation, lung distortion, traction bronchiectasis/bronchiolectasis, honeycombing, and nonemphysematous cysts. 1,2 In some cases, ILA may represent an early form of pulmonary fibrosis. [1][2][3] ILA affects about 7% of the general population. The prevalence varies with age and with smoking habits, being more prevalent in older and smoker individuals. 1,3,4 These patients present more respiratory symptoms and changes in respiratory function tests, particularly with a decrease in forced vital capacity. [5][6][7] This entity seems related to raised proinflammatory molecules that lead to radiological changes. 4 This radiological concept has clinical implica-

Objective: To evaluate the effectiveness of treatment with elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) and to characterize its safety profile in cystic fibrosis (CF) patients in a real-world clinical setting. Methods: This was a prospective observational study carried out in a CF referral center in Portugal involving adult CF patients who started treatment with ELX/TEZ/IVA. Clinical characteristics of the patients were collected, and effectiveness and safety data were evaluated. Results: Of the 56 patients followed in the center at the time of the study, 28 were eligible for ELX/TEZ/IVA treatment in accordance with the Portuguese National Authority for Medicines and Health Products at the time of the study. Of these, 24 met the follow-up time requirement to be included in the clinical effectiveness analysis. The mean follow-up time was 167.3 ± 96.4 days. Adverse events were generally mild and self-limited. Significant improvements in lung function, BMI, sweat chloride concentration, and number of pulmonary exacerbations were observed. No significant differences in outcomes between F508del homozygous and heterozygous patients were found. The effectiveness of this new CFTR modulator combination also applied to patients with advanced lung disease. Conclusions: Treatment with ELX/TEZ/IVA showed effective improvement in real-world clinical practice, namely in lung function, BMI, sweat chloride concentration, and number of pulmonary exacerbations, with no safety concerns.

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Results: This study includes 450 patients, 141 (31.33%) patients had EGFR mutations, of which six (4.25%) had double exons EGFR mutations. Of the six cases with double mutations, male to female ratio was 1:1. The histological patterns reported in the double mutations were: 3 (50%) cases with acinar pattern, 2 (33.33%) with micropapillary pattern, and 1 (16.66%) solid pattern. The median age of the six patients is 54 years (range 38-78).