DEAR EDITOR, In familial hidradenitis suppurativa (HS), mutations in the genes encoding three subunits of the gamma secretase complex, presenilin-1 (PSEN1), presenilin enhancer (PSENEN) and nicastrin (NCSTN), have pointed to impaired Notch signalling as a pathogenic disease mechanism. 1 Dowling-Degos disease (DDD; MIM 179850, 615327 and 615696), a rare reticulated pigmentary disorder, has also been
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