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--Introduction: Necrotizing sialometaplasia is an inflammatory, rare and benign pathology, affecting particularly minor salivary glands. Observations: A case of deep and persistent ulceration of the oral floor associated with sensitivity disorders is reported. Three biopsies were realized, each concluding to a nonspecific ulceration. Local treatments by triamcinolone injections and laser CO 2 were tested. After 18 months of follow-up, a partial regression of the lesion was observed and the patient did not have any sensitivity disorders. Comments: This ulceration was clinically evocative of malignant neoplasia, which was reversed by histology. Others causes of ulceration were excluded on clinical and biological arguments. By elimination, a diagnosis of necrotizing sialometaplasia of the sublingual gland was made. Conclusion: Only one case of necrotizing sialometaplasia of sublingual gland has already been published. The case described here is exceptional due to the low prevalence of the lesion and the chronic ulcer evolution.

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Introduction: Palbociclib is an approved drug in the treatment of women with advanced or metastatic estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative, breast cancer. The purpose of this article is to present the first case ever described of oral ulcers caused by palbociclib. Observation: A case of drug-induced oral ulcers is reported. The patient was treated with a combination of palbociclib and Fulvestrant for a breast cancer relapse with pulmonary involvement. These ulcers were localized on the ventral face of the tongue and on the gum. A therapeutic combination of infrared laser biostimulation and a topical application of Dermoval® and Dynexan® were carried out. Palbociclib was concurrently discontinued. The lesions healed in about 15 days. Comments: Palbociclib is an inhibitor of cyclin-dependent kinases 4 and 6 (CDK 4/6). Thereby, it blocks many signaling pathways responsible for cell proliferation. This property weakens the oral mucosa and could be the cause of the observed ulcers. These latter having been particularly debilitating for the patient. Conclusion: Palbociclib-related oral aphthous ulcers are similar to those reported with other targeted therapies. The combination of infrared laser biostimulation and local corticosteroid therapy did not prevent the discontinuation of the cancer treatment.

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