These results suggest that oxidative damage may play a role in the pathogenesis of acne; therefore, significant alterations may occur in the antioxidant defence system.

A double-blind, randomized study was designed to determine the efficacy of dexamethasone in decreasing periorbital edema and ecchymosis after rhinoplasty. Sixty rhinoplasty patients undergoing hump resection and lateral osteotomy were included in the study and were divided into 6 groups: group 1 (n = 10), single dose of 8 mg intravenous (IV) dexamethasone 1 hour before the operation; group 2 (n = 10), single dose of 8 mg IV dexamethasone at the beginning of the operation; group 3 (n = 10), 3 doses of 8 mg IV dexamethasone 1 hour before the operation, and 24 and 48 hours after the operation; group 4 (n = 10), 3 doses of 8 mg IV dexamethasone at the beginning of the operation, and 24 and 48 hour after the operation; group 5 (n = 10), 3 doses of 8 mg IV dexamethasone immediately after the operation, and 24 and 48 hours after the operation; group 6 (n = 10), control, no dexamethasone administration before or after the operation. Intraoperative blood loss was recorded for each patient. Patients were evaluated at 24 hours and days 2, 5, 7, and 10. For the postoperative evaluation of periorbital ecchymosis and edema, a scale of 0 to 4 points was used. There was no significant difference between groups in terms of bleeding (P > 0.05). In the groups using steroid before osteotomy, edema and ecchymosis were significantly lower during the first 2 days compared with the control group (P < 0.05). No significant difference was seen between groups 1 and 2. When patients were evaluated on day 5, edema and ecchymosis were significantly lower in groups 3 and 4 (P < 0.05) compared with other groups, but there was no difference between them. Group 5 had a significantly higher level of edema and ecchymosis compared with groups 1 through 4 at 24 hours and at days 2, 5, and 7 (P > 0.05). There was no significant difference between groups on day 10. In conclusion, if the first dose is given before osteotomy, triple-dose steroid application is the best bet for decreasing postoperative edema and ecchymosis. None of the patients had any complications related to the use of dexamethasone.

Anticoagulant use is common in the elderly population. The role of these medications in the postoperative period is not well defined. We designed a prospective study to evaluate the incidence of postoperative complications in patients taking aspirin and warfarin. A prospective study was performed on 102 patients undergoing minor cutaneous plastic surgery. The number of subjects using regular aspirin, warfarin, and that of the patients with no anticoagulant medication were 37, 21, and 44, respectively. Complications were defined as minor, moderate, or major based on predetermined criteria. Of patients taking warfarin, 57% had some complication, significantly more than complications in the control group. The number of major complications in the warfarin group was significantly higher than those of the control and aspirin groups (p = 0.02). Also, the total number of complications in the warfarin group was significantly higher than the control group, but there was no significant difference between aspirin and control groups (p > 0.05). Cutaneous surgery in patients who receive warfarin is associated with a risk of major complication, but this risk does not exist in the patients receiving chronic aspirin treatment.

ÖzetAmaç: Bu retrospektif araştırmada alerjik kontakt dermatit (AKD) tanısı ile takip edilen 304 olgunun Avrupa Standart Seri ile uygulanan yama testi sonuçları değerlendirildi. Çalışmanın amacı AKD tanılı olgularda farklı duyarlandırıcalara karşı pozitif reaksiyonların sıklığını bulmak, cins ve yaş farklılıklarını tespit etmek idi. Gereç ve Yöntem: Kliniğimize Ocak 2003-Aralık 2008 tarihleri arasında başvuran, AKD düşünülerek 22 maddelik Avrupa Standart Serisi ile yama testi uygulanan 195'i (%64,1) kadın, 109'u (%35,9) erkek toplam 304 olgu değerlendirildi. Test sonuçları uygulamadan 48 ve 72 saat sonra Uluslararası Kontakt Dermatit Araştırma Grubu'nun önerisine göre okundu. Bulgular: Alerjik kontakt dermatit lezyonları en sık ellerde (%65,5) saptandı. Doksan beş olguda (%31,3) bir veya daha fazla maddeye karşı pozitif reaksiyon elde edildi. En sık duyarlandırıcının nikel sülfat (%14,8) olduğu, bunu kobalt klorid (%9,2), potasyum dikromat (%6,6), peru balsamı (%3,6), koku karışımı (%3,3), merkaptobenzotiazol (%3) ve kolofoninin (%2,3) takip ettiği görül-dü. Nikel sülfat ile pozitif reaksiyon veren olgular çoğunlukla genç yaş grubundaki kadınlardı. Formaldehit ile hiçbir olguda pozitif reaksiyon görülmezken, lanolin, merkapto karışımı, epoksi reçinesi, paraben karışımı ve kuaterniyum-15 gibi maddeler nadir alerjen olarak saptandı. Pozitif reaksiyon veren olguların %51,6'sında sorumlu alerjen Avrupa Standart Serisi kullanılarak bulundu. Sonuç: Bu araştırma ülkemizde olduğu gibi bölgemizde de metal ve koku karışımına bağlı duyarlanma oranının halen yüksek ve genel olarak kadınlarda erkeklerden daha fazla olduğunu göstermesine rağmen, olgu sayısının fazla olduğu çok merkezli prospektif araştırmalar ülkemizde Avrupa Standart Serisinin yeterliliğini daha iyi ortaya koyacaktır. (Türk derm 2011; 45: 198-202) Anah tar Ke li me ler: Alerjik kontakt dermatit, yama testi, Avrupa standart serisi, retrospektif araştırma Sum maryBackground and Design: In this retrospective study, patch test results of 304 patients with allergic contact dermatitis (ACD), who were tested with the European Standard Series, were evaluated. The aim of the study was to determine the frequency of positive reactions to different sensitizers in patients with ACD and to identify sex and age differences. Results: Lesions of ACD were found to be most frequent on the hands (65.5%). A total of 95 (31.3%) patients had one or more positive patch test reactions. The most common allergens were nickel sulfate (14.8%) followed by cobalt chloride (9.2%), potassium dichromate (6.6%), balsam of Peru (3.6%), fragrance mix (3.3%), mercaptobenzothiazole (3%) and colophonium (2.3%). Positive reactions to nickel sulfate were more common among women, especially those in younger group. Frequency of contact allergy to lanolin, mercapto mix, epoxy resin, paraben mix and quaternium-15 were relatively low, while no positive reaction was obtained to formaldehyde in any case. In 51.6% of patients with positive reaction, the responsible allergen was detected by testing with th...

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