Steroids U 0300Derivatives of Exemestane -Synthesis and Evaluation of Aromatase Inhibition.-Several derivatives of the irreversible aromatase inhibitor exemestane (IV) are synthesized, which show reduced inhibitory potency towards aromatase compared to the parent compound (IV). -(GOERLITZER*, K.; BONNEKESSEL, C.; JONES, P. G.; PALUSCZAK, A.; HARTMANN, R. W.; Pharmazie 61 (2006) 7, 575-581; Inst. Pharm. Chem., TU Braunschweig, D-38106 Braunschweig, Germany; Ger., Abstr. Eng.) -M. Kowall 44-185

Steroids Steroids U 0300Unexpected Formation of an Estrone Derivative from Androsta-1,4-diene-3,17-dione. -Acid-catalyzed reaction of androsta-1,4-diene-3,17-dione (I) with pyrrolidine in toluene yields unexpectedly the estrone derivative (III) although in poor yield. The structure of (III) is confirmed by an X-ray structure analysis. -(GOERLITZER*, K.; BONNEKESSEL, C.; JONES, P.-G.; KAUFMANN, G.; Pharmazie 57 (2002) 12, 808-810; Inst. Pharm. Chem., TU Braunschweig, D-38106 Braunschweig, Germany; Ger., Abstr. Eng.) -M. Bohle 16-185