An isocratic, reversed phase-liquid-chromatographic method was developed for the quantitative determination of Levofloxacin and Cefpodoxime proxetil in combined-dosage form. Alliance -Waters System with Agilant Zorbax Eclipse XBD-C8, (150mm×4.6; 5µm) column with mobile phase containing water with Ortho phosphoric acid: Methanol in the ratio of (80: 20, v/v) was used. The flow rate was 0.5 ml/min, column temperature was 40°C and effluents were monitored at 270 nm. The retention times of Levofloxacin and Cefpodoxime proxetil were 3.096min and 4.559min, respectively. The correlation co-efficient for Levofloxacin and Cefpodoxime proxetil was found to be 1.0 and 1.0, respectively. The proposed method was validated with respect to linearity, accuracy, precision, specificity, and robustness. Recovery of Levofloxacin and Cefpodoxime proxetil in formulations was found to be in the range of 97-103% and 97-103% respectively confirms the non-interferences of the excipients in the formulation. Due to its simplicity, rapidness and high precision. The method was successfully applied for the estimation of Levofloxacin and Cefpodoxime proxetil in combined dosage form.