Targeted drug delivery system is a unique type of medication conveyance framework where the pharmacologically dynamic specialists mainly focused on its site activity and not to the non-focused on organs, tissues or cells. Nano sponges are such sort of compelling pharmaceutical transporters, which take care of issues like harmfulness and helpless bioavailability such as they can stack both hydrophilic and hydrophobic medicines. Various classifications of medications can stack into Nano sponge for focused medication conveyance. This targeted drug delivery system is one of the most encouraging methodologies in the existence of science. Nano sponges are little in size with a three-dimensional organization and nanometric depression. Nano sponges are exceptionally permeable and have the extraordinary capacity to ensure dynamic particles and offer programmable delivery. This Review article explains the overall presentation of nano sponges a grouping of nano sponge trademark highlights of nano sponges their points of interest inconveniences, and synthetic compounds utilized in their planning, arrangement of technical factors influencing on the preparation component activities and assessment boundaries with some particular applications.  Keywords: Nano sponges; Targeted drug delivery; Solubility Enhancement; controlled drug delivery.