Introduction: Since conflicting evidence from systematic reviews and meta-analyses (SRs/MAs) on the effectiveness of acupuncture in the treatment of postpartum depression is observed. To systematically collate, appraise and synthesize the evidence from these SRs/MAs, an overview will be performed, and this study is an overview protocol. Methods and analysis: Eight databases will be searched: Medicine, Web of science, Cochrane Library, Embase, China National Knowledge Infrastructure, SinoMed, VIP, and Wanfang Data. SRs/MAs of acupuncture on postpartum depression will be included. Literature screening, data extraction, and evaluation of the review quality will be performed by 2 independent reviewers. The methodological quality, reporting quality, and evidence quality will be assessed using the assessment of multiple systematic reviews-2 tool, the preferred reporting items for systematic reviews and meta-analyses checklists, and the grading of recommendations, assessment, development, and evaluation system, respectively. The results will be presented in the context of the topic and the objects of the overview. This study will help bridge the implementation gap between clinical evidence and its translation in clinical application, identify flaws in research and guide future high-quality study.

group was decreased, but it was increased in EA andE2group. The BDNF protein in hippocampal CA1 area of rats in model group was decreased in both immunohistoc-hemical staining and western blot assay, which showed increasedBDNF expression in EA group. Interestingly, TrkB expression was unchanged in EA group in immunohistochemical staining, but it was found increased expression in western blot assay, while it showed decreased expression in model group.Conclusions:Ovarian removal inhibited the expression of ERα, BDNFandTrkB protein in hippocampus CA1 region and decreased the learning and memory ability of rats. Acupuncture can improve the learning and memory ability of ovariectomized rats by up-regulating the BDNF/TrkBpathway expression in the hippocampal CA1 region, which is one of the mechanisms of acupunc-ture on improving the memory dysfunction in ovariectomized rats. Control drugHaloperidol provided by the Aladdin reagent factory, 2 mg/piece, batch number：20141102. Haloperidol group clinical adult dose (2 mg/70kg ), equivalent dose of 0.26 mg/（kg.d) converted into mice.Haloperidol tablets at the end of the research into distilled water mixture concentration is 0.013 mg/ml suspension,the bottle seal 4℃ temperature refrigerator to the next time.1.1.3 Subjects drugs Shiwei-Wendan decoction(pinellia 15g,acid -insoluble ash 10 g ,dried tangerine or orange peel 15g, tuckahoe 15g, liquorice 10 g,semen ziziphi spinosae 15 g, polygala 10 g, ginseng 15g,rehmannia glutinosa 15g,-fructus schisandrae 15 g) .1.2 Experiment animal kunming species mice,clean level,male,the weight of 25 to 30 g, heilongjiang university of Chinese medicine SCXK (black),batch number:2013-004.2 Experimental Method 2.1 Grouping and drug delivery 30 male KM mice were randomly divided into model group, Shiwei-Wendan decoction group and haloperidol group,each 10,In addition to the model group was given distilled water, the rest of the group are to fill the stomach subjects drugs of the same volume,0.4ml/20g,2 times/d,continuous dosing.2.2 Building dosing and measure before the experiment ,Groups of mice can eat food but not drink water about 12 hours,before and after lavage 3、10 d ,Pargyline hydrochloride subcutaneous injection of 75 mg/kg,after 1 hour to lavage above every medicine (before drug delivery to determine but not to fill medicine ,others the same),Again after an hour the intraperitoneal injection of 5-hydroxy tryptophan about 20 mg/kg, groups of parallel operation,The mice'shaking the head behavior is observed after 25 min,To glance shaking the header record 5 minutes.2.3 Data processing All the data using SPSS 17.0 statistical analysis software .3 Results

Pharmacological method state is a kind of reasoning mode about performance theory of traditional Chinese medicine， which can be used to explore the usefulness and effective medicines principles. The reasoning mode thinks that shape, color, smell, origin, ripening season will affect function of the drug. Pharmacological method state can enrich medicine property of Traditional Chinese medicine on some extent， and it will make the clinical medication change from experience to theoretical. The reasoning mode is useful to recognize the efficacy of Traditional Chinese medicine and explain the principles of effective with orientation analogy law，which can summarize the method of administration and law. It is necessary to clarify this issue that pharmacological method state has a kind of simple, mechanical reasoning and obvious limitations, which has negative impact on the research of the nature of drug action.

Background: The cause of schizophrenia is still unknown, the course of the disease is long and its onset is thought to be related to neurodevelopmental, genetic, and oxidative stress factors and so on. There is no means of cure. Typical drug therapy is effective in treating the acute stage of schizophrenia, while the impaired social and life functions of patients are often neglected. Baduanjin is a traditional Chinese physical and breathing exercise that not only strengthens the muscles, and moves the joints, but also exercises the will. Many studies have been reported in the study on the application of Baduanjin to schizophrenic patients to promote recovery, but no research systematically evaluates the therapeutic effects and safety of Baduanjin for schizophrenic patients. This study aims to systematically investigate the efficacy and safety of Baduanjin in the treatment of schizophrenic patients.Methods: Reports of randomized controlled trials (RCTs) on Baduanjin for schizophrenia will be searched in the following data sources, including 3 English databases(PubMed, EMBASE, Cochrane Library)and 4 Chinese databases(China National Knowledge Infrastructure, Chinese Biomedical Literature, Wanfang, and China Clinical Trials Registry Database), and their publication time is restricted from the establishment of the database to October 1, 2022. Two reviewers will independently perform study selection, data extraction, and quality assessment. RevMan V.5.4 software will be used for meta-analysis. The protocol will be performed according to preferred reporting items for systematic reviews and meta-analysis protocols (PRISMA-P) guidelines.Results: The results will provide a systematic overview of the current evidence on the use of Baduanjin to treat schizophrenia. Conclusion:The conclusions of this study will help clarify whether Baduanjin is effective and safe for treating schizophrenia.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing coronavirus disease , has been devastated by COVID-19 in an increasing number of countries and health care systems around the world since its announcement of a global pandemic on 11 March 2020. During the pandemic, emerging novel viral mutant variants have caused multiple outbreaks of COVID-19 around the world and are prone to genetic evolution, causing serious damage to human health. As confirmed cases of COVID-19 spread rapidly, there is evidence that SARS-CoV-2 infection involves the central nervous system (CNS) and peripheral nervous system (PNS), directly or indirectly damaging neurons and further leading to neurodegenerative diseases (ND), but the molecular mechanisms of ND and CVOID-19 are unknown. We employed transcriptomic profiling to detect several major diseases of ND: Alzheimer 's disease (AD), Parkinson' s disease (PD), and multiple sclerosis (MS) common pathways and molecular biomarkers in association with COVID-19, helping to understand the link between ND and COVID-19. There were 14, 30 and 19 differentially expressed genes (DEGs) between COVID-19 and Alzheimer 's disease (AD), Parkinson' s disease (PD) and multiple sclerosis (MS), respectively; enrichment analysis showed that MAPK, IL-17, PI3K-Akt and other signaling pathways were significantly expressed; the hub genes (HGs) of DEGs between ND and COVID-19 were CRH, SST, TAC1, SLC32A1, GAD2, GAD1, VIP and SYP. Analysis of transcriptome data suggests multiple co-morbid mechanisms between COVID-19 and AD, PD, and MS, providing new ideas and therapeutic strategies for clinical prevention and treatment of COVID-19 and ND. Abbreviations: ACE2 = angiotensin-converting enzyme 2, AD = Alzheimer's disease, BBB = blood-brain barrier, CNS = central nervous system, COVID-19 = coronavirus disease, DEGs = differentially expressed genes, GO = gene ontology, GRN = gene regulatory network, HG = hub gene, KEGG = Kyoto Encyclopedia of Genes and Genomes, miRNA = micro RNA, MS = multiple sclerosis, ND = neurodegenerative diseases, PD = Parkinson's disease, PPI = protein-protein interaction network, SARS-CoV-2 = syndrome coronavirus 2, TFS = transcription factors.