Mobile health applications are known as any wireless technology in medical care and have been considered as one of innovative ways to assist and engage patients in care. This project focused on mobile health applications that were designed specifically for HIV medication adherence and to serve People Living with HIV/AIDs (PLWHA) with their HIV care in Rhode Island (RI) Ryan White Part B program, a federal program that provide HIV care to PLWHA (HRSA,2019). RI-Ryan White program partnered with 360 Medlink, Inc. (a software development company) developed and delivered two advanced digital platforms called TAVIE-HIV (an application with no gamification) and TAVIE-RED (an application with gamification) to Ryan White’s clients in RI.