Background: - Acute pancreatitis is a disease of miscellaneous etiology present as acute abdomen, Inflammatory process of pancreas associated with local and systemic complications. As of now, many scores (such as Ranson’s, APACHE II, Bedside index for severity in acute pancreatitis) that help us in predicting severity at the time of admission. The advantages of the PANC 3 score are to employ widely available tests that are quickly performed and easy to measure. The aim of the present study was to evaluate the efficacy of the PANC 3 score in predicting severity of acute pancreatitis and its relation with the clinical outcome of the disease Aim and Objective: - PANC-3 score in predicting the severity of acute pancreatitis. Materials and Methods: -The PANC 3 score was determined by measuring three variables obtained within the first 24 h after diagnosis of acute pancreatitis: 1) Haematocrit; 2) body mass index (BMI); and 3) pleural effusion on the chest X-ray. It is a prospective study in which 60 patients were evaluated with PANC3 Scoring, who were diagnosed with acute pancreatitis and admitted to DEPT OF GENERAL SURGERY, K.S. HEGDE MEDICAL ACADEMY, MANGALORE Result: - The results showed that PANC3 score had a sensitivity of 80%, and the specificity was 95.5%. The PPV was 85.7%, and the NPV was 93.5%, the diagnostic accuracy is 91% in predicting severe acute pancreatitis. Conclusion: -PANC3 SCORE is a useful tool to approach and predict the severity of acute pancreatitis, due to its high efficacy, easy application and rapid results, which enables classification of cases and early treatment