No abstract

Several novel pyrimidine associated thiazolidines (5a-f) have been synthesized by using 6-trifluoromethyl-pyrimidine-4-ol (1) as starting material and by participating (6-trifluoromethyl-pyrimidine-4-yloxy)acetic acid ethyl ester (2) (6-trifluoromethyl-pyrimidine-4-yloxy)acetic acid hydrazide (3) and (6-trifluoromethyl-pyrimidine-4-yloxy)acetic acid benzylidene-hydrazides (4a-f) as intermediates through substitution, condensation and cyclization. The chemical structures of all the newly synthesized compounds were confirmed by IR, 1 H and 13 C NMR, mass spectral studies and elemental analysis. Further, the synthesized products were screened for their antibacterial activity and the zone of inhibition was measured.