AIMS:To assess the efficiency of fine needle aspiration cytology (FNAC) in the diagnosis of bone lesions. PATIENTS AND METHODS: This Prospective study was conducted in the surgical wards at tertiary care hospital of the Miraj city over two year period from October 2012-September 2014.Thirty seven patients presented with bone lesions were included in this study. The lesions were provisionally diagnosed by clinical and radiological methods. RESULTS: The results of the aspirated lesions include 20 malignant lesions, 8 tumour like lesions, 5 benign and potentially malignant lesions and 3 inflammatory lesions. In one aspirate the materials was inadequate. The results were compared with the histopathological diagnosis. CONCLUSION: FNAC of bone lesion is safe, quick, easy, economical and helpful in planning the correct therapy. KEYWORDS: FNAC, Bone Lesion. INTRODUCTION:FNAC of bone lesions was introduced in 1930s. Experience in this field has revealed high rate of accuracy. The high rate of accuracy of FNAC of bone lesions. (1,2,3,4,5) has resulted in recommending the use of this technique as the first line of investigation of bone lesions. (6) The technique has not been tried in our locality. Therefore this study was planned to assess the efficiency of this technique in our locality.