3-Alkylidene-1,3-dihydroisobenzofurans exhibited moderate antidepressant activity as evaluated by forced swim and tail suspension test methods. Virtual screening was carried out by docking the designed compounds into the serotonin binding sites of arabinase protein to predict the analogue binding mode of the compounds to the SSRIs.

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Phthalanes (II) and (IV) are obtained regio‐, stereo‐, and chemoselectively by Cu(II)‐catalyzed cycloisomerization of 2‐ethynylbenzyl alcohols.

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