P. Biginelli reported the synthesis of functionalized 3, 4 dihydropyrimidine-2 (1H)-ones via three component condensation of an aromatic aldehyde, urea and ethylacetoacetate. This multicomponent reaction is of much importance due to excellent pharmacological properties of dihydropyrimidines. In this account, we synthesized some halo substituted indole dihydropyrimidines and evaluated their antimicrobial activity. The minimum inhibitory concentration (MIC) was determined by micro dilution technique in Mueller-Hinton broth. The MICs were recorded after 24 hours of incubation at 37 °C. These results are promising, showing these compounds are biologically active.

The novel class of multi-substituted indolylimidazole derivatives series substituted 3-(4,5-diphenyl-1H-imidazol-2-yl)-1H-indole and substituted 5-bromo-3-(4,5-diphenyl-1H-imidazol-2-yl)-1H-indole was synthesized utilising a green and efficient one-pot four components condensation of indole-3-carbaldehyde, benzil, ammonium acetate and various amines under microwave irradiation using Amberlyst A-15 as a recyclable catalyst. The catalyst Amberlyst A-15 has recovered from the reaction mixture and reused repeatedly for the next reaction. The key advantage of this process involves eco-friendly, very short reaction time, cost-effectiveness with the reusability of catalyst, easy workup, and purification of the product with excellent yields. FTIR, 1HNMR and Mass spectrometric studies analyzed and established the structures of all newly synthesized compounds.

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Indolylimidazole compounds that contain both indole and imidazole rings have shown various biological and pharmacological activities. These indolylimidazole compounds have been synthesized and extracted from the plants. In this paper, we have reviewed biological activities of natural and synthesized indolylimidazoles and their various synthetic methods. In recent time, the substituted indolylimidazole derivatives have synthesized and reported in the presence of different kind of the catalysts such as strong protic acid HNO3@nano SiO2, Zn 2+ @KSF and acetic acid and Amberlyst A-15. This review paper is divided into two categories bases on bioactivities of natural and synthesized indolylimidazole derivatives.