No abstract

As the heavy metal contamination is becoming worse, monitoring the heavy metal content in water or human body gets more and more important. In this research, a cadmium ion-selective field effect transistor (Cd-ISFET) for rapidly detecting cadmium ions has been developed and the mechanism of the sensor is also investigated in depth. Our Cd-ISFET sensor exhibits high sensitivity beyond the ideal Nernst sensitivity, wide dynamic range, low detection limit (∼10−11M), which is comparable with inductively coupled plasma mass spectrometry, and easy operation enabling people to detect cadmium ion by themselves. From the analysis of electrical measurement results, this Cd-ISFET is preferred to operate at the bias with the maximum transconductance of the FET to enhance the sensor signal. The AC impedance measurement is carried out to directly investigate the mechanism of an ion-selective membrane (ISM). From impedance results, the real part of the total impedance, which is the resistance, was shown to dominate the sensor signal. The potential drop across the ISM is caused by the heavy metal ion in the membrane, which is employed to the gate of the FET via an extended gate electrode. Cadmium ion detection in one drop of human serum with this sensor was demonstrated. This cost-effective and highly sensitive sensor is promising and can be used by anyone and anywhere to prevent people from cadmium poisoning.

Based on finite element analysis software ANSYS, the deformation and force condition of the rubber sealing o-ring pre and post with back-up ring under different oil pressure conditions was analyzed. The von mises stress distribution of the o-ring and the change of contact pressure between o-ring and sealing interface pre and post with back-up ring under different oil pressure conditions were discussed. The results show that, the maximum von mises stress of the o-ring is smaller and the maximum von mises stress of the sealing system concentrates on the left top and the right bottom of the back-up ring after using it; the o-ring will not be extruded into the gap of the groove because of the existence of back-up ring which prevents gap-bite and prolongs service life of the o-ring; the contact pressure between o-ring and sealing interface increased, thus the sealing reliability of the system increased.

In this work, we develop a portable measurement system to detect the critical UV dose for cells, and we can make precautions to prevent people from skin cancer. In this research, we have developed a rapid and highly selective array using field-effect-transistor-based biosensor to monitor the real time electrical signal change of cell membranes. According to the difference of the electrical response, it is possible to predict when cells are undergoing apoptosis dynamically. All in all, our sensor can detect the signal change of cells when they are stimulated by outside environment.