OBJECTIVE:The first aim was to integrate commonly used tinnitus measures into a comprehensive questionnaire. Second, the effectiveness of a masking therapy based on multiple-frequency matching was verified in a clinical study. This study investigated the feasibility of a new treatment strategy for tinnitus, with two main foci. MATERIALS and METHODS:Compare multiple-frequency matching with traditional masking therapy (Single-frequency matching) through clinical trials. The analysis indicated that the reliability and construct validity of the comprehensive questionnaire need to be improved, and the feasibility of the integration attempt remains uncertain. RESULTS:The clinical results showed that the multiple-frequency matching method was more effective than single-frequency matching for tinnitus treatment. CONCLUSION:The multiple-frequency approach should be used more often with tinnitus masking to promote the patients' recovery.