Lysine supplement has been described to be favorable for heart disease and atherosclerosis patients. Positively charged lysine residues in basic human proteins can attract chloride ion which solubilizes insoluble and stiff calcium oxalate and other insoluble salts. Therefore, lysine supplement can alleviate calcium oxalate stress and prolong lifespan to people with constipation, heart disease, Alzheimer’s disease, SARS, SARS-CoV-2, renal stones, etc., since individuals with these disorders possess insoluble salts in their bodies. To reduce cancer risk while achieve a long and healthy lifespan, weak organic acids can be integrated with lysine supplement and dietary regimens, as they minimize risks for tumorigenesis. This remedy could also be effective for heart disease patients.

Methylations are widespread in the biological kingdom. However, their chemical and biochemical roles have not been fully dissected. A hypothesis was put forward previously in which methylation is proposed to lead to hyperconjugation, whose electron donating feature weakens the chemical bonds and increases the bond lengths of C-N, therefore resulting in stronger secondary bonding between nitrogen atoms and cations or protonation of nitrogen atoms. Consequently ion homeostasis of the cells is compromised giving rise to certain diseases. Protonation of nitrogen atoms in 5-methyl cytosine enhances interaction with negatively charged phosphate groups and contributes to the formation of heterochromatin.

As an anti-inflammatory hormone, dexamethasone may minimize proton buildup and down-regulate the production of oxalate. The reduced generation of insoluble and stiff calcium oxalate might account for the substantial drop of mortality rates by dexamethasone amid the current COVID-19 pandemic.

Ebola-like viruses could depend on chloride or HCl to deliver lethal assault on human cells, causing hemorrhaging, bleeding, diarrhea, etc. It may harbor stressful peptides which can be generated in vivo after infections. Fasting with boiled rice water or with orange juice for a few days can halt virion production. However, infection-triggered cell lysis can produce nutrients for viral proliferation. The adoption of weak organic acids such as acetic acid or lactic acid for smearing skin or soaking feet can neutralize chloride or HCl after absorption, and raise cellular pH to minimize cell lysis. Integration of fasting/fruit juice intake and weak acids might reduce mortality rates of Ebola-like virus infections. The intake of NaCl should be minimized as it can give rise to chloride or HCl in cell microenvironment. Many food ingredients such as vinegar and sauce contain salt. Clinical trials must be conducted before the regimen is available for use.

Hypertension is the greatest risk factor for stroke. It is the most common comorbidity of COVID-19, and may be partly caused by the widespread distribution of insoluble and stiff calcium salts such as calcium oxalate. As an intrinsic defensive mechanism, tissues in hypertensive individuals increase blood pressure to pump NaCl to inaccessible parts of the body, and chloride, as a strong anion can solubilize insoluble and rigid salts which are stressful to cells.