Esophageal cancer is a major public health problem and social burden in China, and it is the fourth leading cause of cancer death with a 8.04% mortality rate in 2015. 1 There are two main types of esophagus cancer: esophageal squamous cell cancer (ESCC) and esophageal adenocarcinoma (EAC). ESCC accounts for more than 90% of the cases in China 2 ; however, since the 1970s, the incidence of EAC has significantly increased
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