Background: Considering the high market share of energy drinks and the number of existing studies examining their erosive properties this systemic review and metanalysis aim at investigating a selected number of relevant in vitro studies  Materials and Methods: This systematic review focuses on a number of in vitro studies selected via the utilization of a configuration tool and their strength of evidence provided and subsequent procedures. Further selection occurred in order to perform a metanalysis.  Results: The systematic review involved assessment of reporting quality, performance bias and other type of bias, all following a configuration of criteria established to serve this purpose. Three grades were used to describe the assessment. In the metanalysis a number of studies were selected that satisfied the requirements set. Results highlighted the erosive properties of the energy drinks. Conclusion: All studies included in this systemic review and metanalysis, showcased the erosive properties of the energy drinks and the requirement for further research.