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ABSTRACT

ABSTRACT

Objectives To determine whether progesterone supplementation alters cervical shortening in women at increased risk for preterm birth. Methods (difference 1.6 (95% CI, mm; P = 0.02, ANCOVA). In the population of 104 subjects with premature cervical shortening at randomization, the cervical length also differed significantly on multivariable analysis, with the treatment group preserving more cervical length than the placebo group (difference 3.3 (95% CI,.2) mm; P = 0.03, ANCOVA), with adjustment for differences in cervical length at screening. A significant difference was also observed between groups for categorical outcomes including the frequency of cervical length progression to ≤ 25 mm and a ≥ 50% reduction in cervical length from baseline in this subpopulation. ConclusionsIntravaginal progesterone enhances preservation of cervical length in women at high risk for preterm birth.